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The Ohio State University

Global Infectious Disease Research

Friday, May 24, 2013
   
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Larry Schlesinger

Email: 
Larry.Schlesinger@osumc.edu
Phone: 
(614) 293-5671
Position: 
Saslaw Professor of Internal Medicine, Professor of Molecular Virology, Immunology, and Medical Genetics and Microbiology
Department: 
Integrated Biomedical Graduate Program
Degree: 
MD
Webpage: 
http://cmib.osu.edu/
Additional Information: 

Recent published articles:

 

·       Carlson TK, Torrelles JB, Smith K, Horlacher T, Castelli R, Seeberger PH, Crouch E, Schlesinger LS. 2009. Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis.  Glycobiology, no. 19: 1473-1484.

·       Chiu H-C, Soni S, Kulp SK, Curry H, Wang D, Gunn JS, Schlesinger LS, Chen C-S. 2009. Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent.  J Biomed Sci., no. 16: 110.

·       Chiu H-C, Yang J, Soni S, Kulp SK, Gunn JS, Schlesinger LS, Chen C-S. 2009. Pharmacological exploitation of an off-target antibacterial effect of the cyclooxygenase-2 inhibitor Celecoxib against Francisella tularensis.  Antimicrob Agents and Chemotherapy, no. 53: 2998-3002.

·       Cremer TJ, Ravneberg DH, Clay CD, Piper-Hunter MG, Marsh CB, Elton TS, Gunn JS, Amer A, Kanneganti T-D, Schlesinger LS, Butchar JP, Tridandapani S. 2009. Mir-155 induction by F. novicida but not the more virulent F. tularensis, results in enhanced proinflammatory cytokine response.  *, no. 4: e8508.

·       Day J. Friedman A, Schlesinger LS. 2009. Modeling the immune rheostat of macrophages in the lung in response to infection.  PNAS, no. 106: 11246-11251.

·       Lustberg M. Schlesinger LS, Mangino J. 2009. Concerns regarding "Complicated Skin and Skin-Structure Infections and Catheter-Related Bloodstream Infections: Noninferiority of Linezolid in a Phase 3 Study.  Clinical Infectious Diseases - Letter to the editor. Vol. 49: 313-314.

·       Premanandan C, Storozuk C, Clay C, Lairmore MD, Schlesinger LS, Phipps AJ. 2009. Complement protein C3 binding to Bacillus anthracis spores enhances phagocytosis by human macrophages.  Micro. Pathog.. Vol. 46: 306-314.

·       Sow FB, Alvarez GR, Gross RP, Satoskar AS, Schlesinger LS, Zwilling BS, Lafuse WP. 2009. Role of STAT1 and C/EBP? in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-?.  Journal of Leukocyte Biology, no. 86: 1247-1258.

·       Torrelles JB, DesJardin LE, MacNeil J, Kaufman TM, Kutzbach B, Knaup R, McCarthy TR, Gurcha SS, Besra GS, Clegg S, Schlesinger LS. 2009. Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death.  Glycobiology. Vol. 19: 743-755.

·       Wang S-H, Pancholi P. Stevenson K, Yakrus MA, Butler WR, Schlesinger LS, Mangino JE. 2009. Pseudo-outbreakk of "Mycobacterium paraffinicum" in a tertiary care medical center.  Infections Control and Hospital Epidemiology, no. 30: 848-853.

·       Carlson TK; Torrelles JB; Smith K; Horlacher T; Castelli R; Seeberger PH; Crouch EC; Schlesinger LS. 2009.Critical role of amino acid position 343 of surfactant protein-D in the selective binding of glycolipids from Mycobacterium tuberculosis.  Glycobiology. Vol. 19, no. 12. (December 1): 1473.

·       Chiu HC; Kulp SK; Soni S; Wang D; Gunn JS; Schlesinger LS; Chen CS. 2009. Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent.  Antimicrobial Agents And Chemotherapy. Vol. 53, no. 12. (December 1): 5236-5244.

·       Clay CD, Gunn JS, Schlesinger LS. 2010. Antibody-independent classical complement pathway activation by wildtype and LPS O-antigen mutant Francisella tularensis strains.  Mol Immun. no. 47: 2245.

·       Mohapatra NP, Soni S, Rajaram M, Dang PMC, Reilly TJ, El-Benna J, Schlesinger LS, Gunn JS. Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes by dephosphorylation of p47phox and p40phox.  J Immunology Epub. (Forthcoming)

·       Rajaram MVS, Morris JD, Brooks MN, Torrelles JB, Azad AK, Schlesinger LS. 2010. Mycobacterium tuberculosis activates human macrophage PPAR? linking mannose receptor recognition to regulation of immune responses.  J Immunol. no. 185: 929-942.

·       Torrelles JB, Schlesinger LS. 2010. Diversity in M. tuberculosis mannosylated cell wall determinants impacts adaptation to the host.  Tuberculosis. no. 90: 84-93.

·       Wang S-H, Powell DA, Nagaraja HN, Morris JD, Schlesinger LS, Turner J. 2010. Evaluation of a modified interferon gamma release assay for the diagnosis of latent tuberculosis infection in adult and pediatric populations that enables delayed processing.  Scandinavian Journal of Infectious Diseases. Epub.

·       Day J; Schlesinger LS; Friedman A. 2010. Tuberculosis research: going forward with a powerful "translational systems biology" approach.  Tuberculosis (Edinburgh, Scotland). Vol. 90, no. 1 (January 1): 7.